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Rhythm doctor controls5/29/2023 Rats had to reach for and grab the pellet and retrieve it for successful completion of the trial. Using healthy rats, investigators recorded from the motor cortex and the cerebellar cortex chronically as the animals were trained for five days to perform a fine motor task where they reached for a sugar pellet placed at a distance from them. However, the activity between the motor cortex and the cerebellum that emerges as a fine motor skill is learned is not widely understood. One fundamental projection of the motor cortex is to the cerebellum, the part of the brain that holds more than half the neurons of the entire body. The motor cortex, which is the chief driver of all movement, controls arm movement by recruiting a variety of targets in the nervous system. To better understand changes in the brain during the course of motor learning, investigators looked at brain physiological activity in the motor cortex and the cerebellum in rats as they practiced a skilled reaching task. So, we are looking to understand how the brain generates movement and learns new dexterous/fine motor skills so we can potentially develop novel treatment strategies to repair these disabilities.” “Many patients may be able to reach for the target they want with some recovery, but they are not able to grasp it accurately. “One of the main complaints from stroke patients is that they cannot complete the grasping action,” said Tanuj Gulati, PhD, assistant professor of Neurology and Biomedical Sciences ’ Center for Neural Science and Medicine at Cedars-Sinai and senior and corresponding author of the study. The findings, published in the peer-reviewed journal eNeuro, provide insight into the neural mechanisms of motor skill learning that can help lead to more effective brain-stimulation therapies for patients experiencing motor disability after a stroke. A new study led by Cedars-Sinai investigators identified a marker in the brain that controls the ability to reach and grasp, a fundamental fine motor skill that is often impaired in motor or neural injuries such as a stroke.
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